Christian Dombrowski Email Address

Vice President Gene Editing Platform

Intellia Therapeutics is a leading gene-editing company focused on the development of curative medicines using CRISPR/Cas9 technology

An experienced molecular biologist with a proven track record of complex problem solving, an innate ability to improve existing processes and develop technologies for drug-like properties engineering. Adds value by outside-the-box thinking and thrives in a fast-paced environment that fosters creativity. A strong team player who extends competencies and skill set to areas outside his own domain that cultivates strong interdisciplinary partnerships. TECHNICAL SKILLS: •Standard molecular techniques (cloning, PCR, mutagenesis, mini-circle) •Standard protein techniques (expression, purification, analysis-IP, western blot, SDS-PAGE) •Protein engineering (Fc fusions, dominant-negative, constitutively active) •Complementation assay (luciferase, GFP) •Mammalian/bacterial/yeast cultures •RNA interference (siRNA, shRNA, ASO) •Yeast display (Immunoprediction platform, thermostability engineering) •Fluorescence Activated Cell Analysis and Sorting, Magnetic Cell Sorting •Antibody construction (Variable domain cloning, construction of antibody/Fab/scFv from patent, humanization) •Lentivirus/retrovirus production (high-titer, medium throughput) •Stable cell line establishment for gene knockdown studies, protein production, signaling pathway analysis, etc.