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Denis Phichith Email Address


Job Title

Lead Upstream Cell Line Development and AAV Engineering Team

Spark Therapeutics

Spark Therapeutics is challenging the inevitability of genetic disease by discovering, developing and delivering treatments in ways unimaginable - until now.


Since I have joined the Process Development group, I have been involved and successfully developed: - HEK293 Suspension production of AAVs (small scale to scaling up process) to support several pipeline products. - Adaptation and implementation to increase AAV yields of current production methods relative to HEK293 adherent cells - DOE and scaling studies to support BLA filing for RPE-65 - Engineer Cell Lines - Lentiviruses and Adenoviruses production I have gained a good expertise in the field of AAV manufacturing since I have joined Spark. Moreover, my interaction with the manufacturing team along with my functions within the process development group provided me with a deep understanding of the tech transfer from small scale to large scale AAV production.

Last University
Institut Pasteur
Is based in Philadelphia.

Other people working at Spark Therapeutics:

Jeffrey MarrazzoBoard of Managers
Linda HearneFinance Executive and Financial Operations and Financial Strategy
Irena IgnatovaSenior Scientist
Edward KnechtManufacturing Specialist II
Gurpreet RatraChief Business Officer
Jay NewmanHead of US Marketing and Patient Access
Robin BartlettSenior Director, Information Technology Business Services
Danielle Petrangeli PotteigerVice President, US Marketing
Younghoon OhPD Downstream Lead and Associate Director
Josiah WoodsSenior Project and Operations Manager, Translational Science
Elizabeth JobesSenior Vice President, Chief Compliance Officer North America at EMD Serono Inc
Christian BenitesSenior HRIS Analyst
Lorraine BarkerDirector of Regional Accounts West
Jennifer FlaisherLead Human Resources Business Partner and Head of Talent Development
Stephen OroszSenior Principal Systems Engineer
Lisa DaltonChief Human Resources Officer
Kevin GiordanoLead , External and Product Communications
Ryan AsayAssistant Manager
Ron Philipr*****@sparktx.com
Jamie SchmidHead of Talent Acquisition

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