Shanthi Ganesh Email Address
@dicerna.com
Director, Discovery Research
Delivering RNAi-based breakthrough therapies to improve lives
•15+ years of industry experience in cancer drug discovery, drug delivery, and pharmacology and nucleic acid therapeutics •In vivo pharmacology of experimental cancer therapeutics spanning serveral drug modalities including RNAi therapy, small molecule drugs, oncolytic virus particles and nanotechnology solutions •PK/PD/efficacy modeling of combination therapy to sensitize tumors to cancer immunotherapy and standard-of-care targeted therapeutics and investigate drug resistance mechanisms •Subject matter expert in mouse models of cancer; developed and characterized metastatic, orthotopic, GEMM, PDX and other tumor models •Pharmacodynamic endpoints expertise including FACS, immunohistochemistry, qPCR •Design, generation and evaluation of lipid nanoparticle-based formulations and oncolytic viruses •Leadership and participation on discovery and early development project teams; cross-functional collaboration with nonclinical, CMC, DMPK and business development; management of CROs and external collaborators •Scientific track record of impactful publications, review articles, conference presentations, educational workshops and patents.
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