Paul Wolters Email Address

Vice President, Head of Cardiomyopathy and Heart Failure Clinical Development

MyoKardia is a clinical stage biopharmaceutical company pioneering a precision medicine approach to discover, develop and commercialize targeted therapies for the treatment of serious and neglected rare cardiovascular diseases. MyoKardiaaEUR(tm)s initial focus is on the treatment of heritable cardiomyopathies, a group of rare, genetically-driven forms of heart failure that result from biomechanical defects in cardiac muscle contraction. MyoKardia has used its precision medicine platform to generate a pipeline of therapeutic programs for the chronic treatment of the two most prevalent forms of heritable cardiomyopathyaEUR"hypertrophic cardiomyopathy, or HCM, and dilated cardiomyopathy, or DCM. MyoKardiaaEUR(tm)s most advanced product candidate, MYK-461, is an orally-administered small molecule designed to reduce excessive cardiac muscle contractility leading to HCM and is currently being evaluated in three Phase 1 clinical trials. A cornerstone of the MyoKardia platform is the Sarcomeric Human Cardiomyopathy Registry, or SHaRe, a multi-center, international repository of clinical and laboratory data on individuals and families with genetic heart disease, which MyoKardia helped form in 2014. MyoKardia believes that SHaRe, currently consisting of data from approximately 10,000 individuals, is the worldaEUR(tm)s largest registry of patients with heritable cardiomyopathies. MyoKardiaaEUR(tm)s purpose is to improve the lives of patients and families suffering from cardiovascular disease by creating targeted therapies that can change the course of their condition.

Physician-scientist who keeps patients first. Influential - Strategic - Collaborative - Pragmatic leader with proven track record developing and launching first-in-class, disruptive products transforming medicine. Company and team builder with deep experience at the leading edge of diverse clinical programs from genomic diagnostics to precision therapeutics. Passionate scientist with expertise in study concept design, protocol development, all aspects of study implementation and conduct, analysis, interpretation, medical-scientific communication, and global regulatory filings. Key contributor to products launched in cardiology, genetics, maternal-fetal medicine, and oncology tackling unmet medical needs through innovative science. Mission driven.