Associate Scientist St Jude Children's Research Hospital
St. Jude Children’s Research Hospital is leading the way the world understands, treats and defeats childhood cancer and other life-threatening diseases. St. Jude was established in 1962 and has helped to increase the childhood cancer survival rate from 20% to more than 80% since it first opened its doors. The institution is powered by the great generosity of its donors, which helps ensure that families never receive a bill from St. Jude for treatment, travel, housing or food--so they can focus on helping their child live.
Engineer and innovator with over 20 years of international experience, managing complex and cutting edge projects with research and clinical deliverables. Sector experience spans academic research, pharma, finance and healthcare, including healthcare IT production systems, big data analytics, diagnostic software creation, and machine learning. US Immigration Status: Permanent Resident (EB-1A Immigrant Greencard) ***Research Career Highlights*** Invented and demonstrated the patented use of bacterial artificial chromosomes for high precision, rapid, scalable manipulation of stem cells. Internationally recognized by EMBL curriculum as a critical milestone in genetic engineering, and precursor to CRISPR-Cas9 technology. Development and optimization of protocols for electron microscopy in situ RT-PCR validation of drug targets, implemented at global GSK locations. Development, validation, and optimization of machine learning pipelines which discovered metastatic drug targets from comparative gene expression analysis of both big and noisy datasets originating from cancer and stem cell lines. First to demonstrate long term cell survival following intercellular delivery of bioactive materials by nano-injection. First to demonstrate long term survival and protein expression from delivery of mRNA by nano-injection. Invented, validated, and distributed software used to identify genetic variants in children with rare disorders. Participation in a national competition to discover novel diagnostic approaches for big data. Optimized code and algorithms to return results in less than two hours from whole genome sequences, twenty minutes for exomes. Identified novel variants for known conditions, not served by routine genetic clinical testing, ending a combined diagnostic odyssey of over 40 years for 12 families. ***Healthcare Career Highlights*** Team contributions on implementation and monitoring of successful campus wide infection control measures, in alignment with national government directives, in a healthcare setting. Policy and SOP creation in collaboration with union representatives. Reporting to C-Suite executives, local and national government monitoring. Team contributions on creation, implementation and monitoring of successful de-identification and sample management IT solution campus wide. Collaboration management with Compliance, IT, Research & Development, and Clinical Departments to elicit and achieve consensus on requirements, in alignment with federal and state legislation, in a healthcare setting. Reporting to C-Suite executives.
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