Senior Vice President of R and D Bioinformatics
Computer Sys Design Srvcs
Dr. Chen has developed many databases and software to drive precision medicine, clinical diagnosis, and therapeutic target discovery through collecting and analyzing hundreds of thousands of genomes with health records. He has published over 80 papers in top tier journals, including Lancet, Cell, Nature Biotechnology, Nature Methods, Science Translational Medicine, PNAS, and JCI. He is an Assistant Professor and Director of Clinical Genome Informatics at Icahn School of Medicine at Mount Sinai, established clinical genome informatics laboratory, and led resilience, personalized cancer therapy, clinical exome sequencing, non-invasive prenatal test, and several endocrine tumor sequencing projects. Before joining Mt. Sinai, he has help built a startup company called Personalis to interpret personal genome and exome sequences for clinical diagnosis, and won the sequencing contract from VA Million Veteran program. While working as a research scientist with Atul Butte at Stanford University, he established the largest translational bioinformatics databases, identified clinical diagnostic biomarkers for organ transplant rejection, published the first Clinical Assessment of Human Genome and led the wave of personal genome report. He has also worked in Quest Diagnostics, Abgenix (bought by Amgen), and Accelrys (now known as BIOVIA), analyzed various types of big data, from thousands of protein structures, hundreds of antibody structures, to millions of microarray data, launched several cancer diagnosis assays, and wrote one of most widely used protein-protein software ZDOCK. Specialties: precision medicine, translational bioinformatics, clinical genome informatics, big data, electronic medical records, genetics, genomics, cancer, Alzheimer's disease, organ transplant
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