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Muthiah ('Mano') Manoharan Email Address

abcdefghij@alnylam.com

Job Title

Senior Vice President, Innovation Chemistry and Alnylam Distinguished Scientist

Company
Alnylam Pharmaceuticals

Learn about Alnylam Pharmaceuticals, RNAi therapeutics, and the company's efforts in treating amyloidosis, hemophilia, and porphyria.

Bio

Dr. Muthiah (Mano) Manoharan serves as a Senior Vice President of Drug Innovation, a Scientific Advisory Board Member, and a Distinguished Research Scientist at Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA. In 2003, he was the first chemist hired at Alnylam and built the Drug Discovery team at Alnylam. He and his team pioneered the discovery and development of the chemical modifications that make RNA interference-based human therapeutics possible. This work led to ONPATTRO (patisiran), the first RNAi therapeutic approved by FDA in 2018 for treating TTR amyloidosis mediated polyneuropathy. Dr. Manoharan has had a distinguished career as a world-leading chemist in the areas of oligonucleotide chemical modifications, conjugation chemistry, and delivery platforms (lipid nanoparticles, polymer conjugates, and complex-forming strategies). Dr. Manoharan and his research group designed, synthesized and demonstrated for the first time the human therapeutic applications of GalNAc-conjugated oligonucleotides at Alnylam, a platform that has revolutionized the RNA therapeutics field with several compounds presently in the advanced clinical trials. The very first GalNAc-siRNA conjugate among them, GIVLAARI (givosiran), for the treatment of acute hepatic porphyria (AHP) has been approved by FDA very recently (November 2019). He is an author of more than 215 publications (nearly 44,500 Google Scholar citations with an h-index of 97 and an i10-index of 375) and over 400 abstracts, as well as an inventor of over 240 issued U.S. patents. Prior to Alnylam, Dr. Manoharan worked at Ionis (formerly Isis) Pharmaceuticals (1990-2003; Carbohydrate modifications like 2’-O-MOE and Conjugates) and LifeCodes Corporation (1988-1990) in the field of antisense oligonucleotide therapeutics.

Last University
Yale University
Location
Lives in Weston.

Other people working at Alnylam Pharmaceuticals:

James BilottaSenior Vice President, Chief Information Officer
John M MaraganoreVice President, Financial Solutions Strategy and Research
Akshay VaishnawMember Board of Directors
Beth ShusterAssociate Director, Talent Acquisition
Lynn Newbould MBAChief Sourcing Strategy Officer
Timothy McIntireSenior Director, Global Marketing Lumasiran at Alnylam Pharmaceuticals
Michael MasonChief Financial Officer
Kevin FitzgeraldChief Scientific Officer
Carl MartinSenior Director, Talent Acquisition at Kronos Bio
Mark BaglinChief Commercial Officer
Meredith KayaSenior Vice President, Investor Relations and Strategic Finance
Karen AndersonChief Human Resources Officer
Eap***@alnylam.com
Larry GalbraithAdvisory Board Member
J. Poulton********@alnylam.com
Barry GreeneBoard Member
Jc***@alnylam.com
Thierry Aupérin********@alnylam.com
Anna O'driscollChief People Officer
Len Groves*******@alnylam.com

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